The Effects of Apitherapeutic Agents on Oxidative Stress in Serum Metabolic Parameters of Hypertensive Rats Created by Nitric Oxide Synthase Inhibited

Hypertension is a chronic disease affecting the whole world due to its clinical effects and complications. The reduction in release effect of NO one mechanisms hypertension formation. disrupts balance between oxidant antioxidant mechanisms. In this study, we aimed observe biochemical changes blood by treatment propolis, caffeic acid phenethyl ester (CAPE) pollen hypertensive rats via Nω-Nitro-L-arginine methyl (L-NAME). Rats were divided five groups. given L-NAME (40 mg/kg, intraperitoneally) for 14 days make hypertensive. bee products administered together with days, then days. All administrated ended 28 There was statistically significant (P<0.05) decrease pressure (BP) groups which applied. Blood lower treated group than CAPE propolis (P<0.05). Paraoxanase (PON1), total status (TAS), (TOS), asymmetric dimethylarginine (ADMA), nuclear factor-κB (NF-κB) levels measured samples all group; PON1, TAS, HDL, protein found be applied TOS, oxidative stress index (OSI), ADMA, NF-κB, glucose, cholesterol, LDL, triglyceride, ALT, AST, ALP plus compared that received results showed homeostasis can regulated induced L-NAME.